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91
Eboka Talk / Re: Happy to see the site back up!
« Last post by skinny on May 08, 2018, 07:16:03 AM »
It had been down for a quite a while, was hoping all of the great stories and data on here didn't get lost. Thanks to whoever brought it back.

Lol..I just logged back on today after months forgetting that this site existed!  I mean lots of classic posts here in the archives if you dig down deep.

What I miss the most is that people used to share knowledge and do detailed trip reports.  That's seems to have been lost because of presumably Facebook, the world's most popular social networking platform...which ironically is less about social networking as it is than this site used to be.

skinny
92
Suggestions & Comments / Re: Why is Eboka Dying?
« Last post by skinny on May 08, 2018, 07:12:08 AM »
I'm back.  The above post is the last one I wrote since Eboka.info was down for months...is this forum back online? 

I've been on Facebook but got recently banned (in FB jail for 30 days lol), so I'm looking to reconnect to community.

Are any of the old-timers still on here?  GratefulDad...last I read he was in a coma or really messed up from an iboga flood.  KP...is he still around or managing his Kambo forum?   

Re-reading all my old private messages going back 7 years or so :D

skinny
93
Introductions / Re: Iboga for 90G Kratom addiction.
« Last post by Synesthete on May 06, 2018, 08:59:01 PM »
I'm a little late to the game but this is important info to have.  Kratom is QT prolonging which increases the importance of making sure it's completely out of your system before flooding. If a person has a prolonged QT interval due to medications some experienced clinics will assess them over several days and repeat the EKG until the QT stabilizes and returns to normal. This is not something that should be attempted without the guidance of an experienced provider.  There are also all the extra alkaloids in kratom that we do not fully understand. It appears to impact serotonin levels as some people who were taking SSRI's developed serotonin syndrome after consuming large quantities of kratom.  I can vouch for this first hand. Since SSRI's are also contraindicated with Iboga this is two strikes against using it for kratom withdrawals.
94
Micro-Dosing / Re: Microdosing without previous flood for depression
« Last post by Justbe on May 05, 2018, 04:31:25 AM »
That was my experience too,cuz I didn’t smoke much and compared to the amount I got very sleepy but it also relaxed.
Yesterday, day 5, I increased the dose to 70 mg and felt not different to the other days. Today I’ll take a day off MD just to see how it is.
95
General Discussion / Re: IBOGA FATALITY MYSTERY --- LQTS - WARNING
« Last post by i are spectre on May 05, 2018, 12:50:17 AM »
On top of a routine EKG and abstaining from medication that may increase QT, I suggest coconut water...

from http://nutritiondata.self.com/facts/nut-and-seed-products/3115/2

minerals / ions in 1 quart / ~1 L coconut water
mineral    amt       %DV
Calcium    230.4mg    24%
Iron       2.8mg       16%
Magnesium    240.0mg    60%
Phosphorus    192.0mg    20%
Potassium    2400mg       68%
Sodium       1008mg       44%
Zinc       0.8mg       8%
Copper       0.4mg       20%
Manganese    1.2mg       68%
Selenium    9.6mcg       12%
96
Micro-Dosing / Re: Microdosing without previous flood for depression
« Last post by RhythmSpring on May 03, 2018, 07:33:51 PM »
Try less MJ when on iboga. A little goes a faaar way when microdosing.
97
Micro-Dosing / Re: Microdosing without previous flood for depression
« Last post by Justbe on May 03, 2018, 06:06:33 AM »
Went on with 50 mg daily and feeling relatively comfortable. Before I started MD I quit consuming cannabis as I was smoking daily for years. I hoped the craving for cannabis would be reduced and I would say it was, however yesterday night I couldn’t resist and smoked one more spliff. I slept like a baby but woke up late, which I don’t want. So I’ll try not to smoke anymore,at least until I finished MD. Tomorrow I will try a higher dose I guess.
98
Micro-Dosing / Re: Microdosing without previous flood for depression
« Last post by Justbe on May 01, 2018, 09:08:09 AM »
I started yesterday with 50mg TA. The effects were that I felt somehow trippy first and less fatigue and most important I was in a bullish mood and more active than usual. Another positive effect was I could easily get out of my bed early in the morning, which was very surprising. Today I took the second dose (50mg) and didn’t had that trippy feeling but all the positive effects like yesterday. For a long time I see a light at the end of the tunnel (as you say in German).
99
Introductions / Re: Iboga for 90G Kratom addiction.
« Last post by i are spectre on May 01, 2018, 01:52:02 AM »
did it work man?  what happened?
100
General Discussion / Re: How does Iboga cause heart issues?
« Last post by i are spectre on April 28, 2018, 10:44:31 PM »
Heart issues are dose dependent and not limited to ibogaine.  Noribogaine has been shown to increase QT interval as well...

---

(1) Ascending Single-Dose, Double-Blind, Placebo-Controlled Safety Study of Noribogaine in Opioid-Dependent Patients.

"... There was a concentration-dependent increase in QTcI (0.17 ms/ng/mL), with the largest observed mean effect of ?16, 28, and 42 milliseconds in the 60-, 120-, and 180-mg groups, respectively."

https://www.ncbi.nlm.nih.gov/pubmed/27870477

One thing to note is these people were dependent on methadone and switched to morphine for a week, and that MAY play a role (methadone prolongs QT), but I think noribogaine is to blame for most of that effect.

---

(2) Ascending-dose study of noribogaine in healthy volunteers: pharmacokinetics, pharmacodynamics, safety, and tolerability.

https://www.ncbi.nlm.nih.gov/pubmed/25279818

Now at first this looks like everything is all good, but the doses were MUCH smaller (less than 60mg) than the previous study with opioid dependent individuals.  Under the safety section...

Safety:  "One subject dosed with 10 mg noribogaine had a single increase in QTcF of >60 milliseconds at 24 hours post-dosing."

So I don't know why they decided to use different doses between healthy individuals and opioid tolerant individuals in the first study above, but they did.  Either way, 60ms increase in QT 24 hours after dosing 10mg of noribogaine is very significant... granted it was only one of the ~18 subjects.

---

Unfortunately this is an unwanted side effect that's hard to get by.  Things just love to bind to hERG channels, pharmaceuticals included.    Likewise, I don't feel comfortable telling you that either ibogaine or TA is safer than the other.  My suggestion is to take good care that you don't have any meds in your system that prolong QT, stop smoking if you do smoke, stay well hydrated with water and electrolytes (coconut water!) to maintain potassium ions and sufficient blood pressure, and perhaps even doing some cardiovascular exercise.  Make sure to get an EKG too, and see if your QT isnt already on the long side (500ms+).  Add yes, microdosing would be safer, but if you microdose over and over these compounds will build up.  Maybe find a phone app that can check your QT?

When I did a flood dose, I took small amounts of ibogaine and TA extract for 3 days to ease withdrawal first.  Then I just went all in, and the remainder was 800mg of ibogaine and 800mg of TA for the flood.
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