Author Topic: NO GRAPEFRUIT  (Read 3045 times)

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Offline Jox

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NO GRAPEFRUIT
« on: December 05, 2012, 03:55:05 PM »
Hi all Eboka Nation,

we all know that grapefruit should not be mixed with Iboga(aine), but check this report I found on one cite:

Grapefruits can trigger overdoses in dozens of medicines researchers warn

Millions of people taking medicines for high cholesterol, cancer and to prevent heart attacks are at risk of potentially life threatening side effects if they eat grapefruits, doctors have warned.

By Rebecca Smith | The Telegraph – 5 hours ago

A study has listed 43 major drugs which are affected by eating grapefruits or drinking the juice and experts have warned there needs to be more awareness of the risks.

The number of drugs that interact with grapefruit increased from 17 in 2000 to 43 in 2008, researchers in Canada found.

Eating one grapefruit a day or drinking 200ml of juice was enough to trigger significant side effects in some of the patients.

Elderly patients were at particular risk because they are more likely to eat grapefruit and be on the medicines that interact with it, while their bodies are less able to cope with the effects of an overdose, the researchers said.

Grapefruits and some other citrus fruits, contain specific chemicals that affects an enzyme in the gut which can lead to a greater proportion of the drug being absorbed into the body.

This can result in massive overdoses causing serious side effects ranging from hallucinations, low blood pressure, to kidney poisoning, muscle damage, high heart rate and breathing problems.

The findings were published in the Canadian Medical Association Journal.

Some people have died following the interaction and experts said doctors and pharmacists needed to be more aware of the problem.

The study, conducted by Dr David Bailey, of the Lawson Health Research Institute, in London, Ontario, listed several examples of interactions including one patient who suffered a potentially life threatening increase in heart rate while on the heart disease drug aimodarone and drinking between one and 1.5 litres of grapefruit juice a day.

Another one atorvastatin for high cholesterol suffered serious muscle damage after drinking freshly squeezed grapefruit juice daily for five days and one who developed a blood clot while on Ethinylestradiol, a form of hormone replacement therapy for menopause symptoms who had eaten a whole grapefruit at breakfast for three days.

Popular drugs affected in this way include simvastatin, taken for high cholesterol, clopidogrel to thin the blood, Tyverb for breast cancer, domperidone for sickness and powerful painkillers Fentanyl, Oxycodone and Ketamine.

One drug, dextromethorphan, is an anti-cough preparation used in over-the-counter products and other drugs that interact with grapefruit are some antibiotics, some anti-HIV drugs, quinine that is in tonic water and has been used against malaria, heart rhythm medicines, and anti-rejection drugs used following organ transplants.

For some drugs drinking 200ml of juice daily was enough to deliver three to six times the normal dose.

Dr Bailey said: "Many of the drugs that interact with grapefruit are highly prescribed and are essential for the treatment of important or common medical conditions.

"Unless health care professionals are aware of the possibility that the adverse event they are seeing might have an origin in the recent addition of grapefruit to the patient's diet, it is very unlikely that they will investigate it.

"In addition, the patient may not volunteer this information. Thus, we contend that there remains a lack of knowledge about this interaction in the general healthcare community."

The grapefruit effect can work in both ways, to reduce the amount of drug absorbed by the body, or to increase it, as was studied in this research.

Prof Simon Maxwell, Clinical Lead of Prescribing at the British Pharmacological Society and Professor of Clinical Pharmacology at the University of Edinburgh, said: "There are a lot of drugs on the list, including some very important high volume ones. But they represent a minuscule fraction of the compounds out there.

"Serious interactions are not a massive problem in Britain but we are probably not talking to our patients about it enough and awareness amongst doctors is definitely not high enough."

He said some of the interactions were theoretical such as dextromethorphan used in some cough mixtures as the amount of the active drug used in those medicines was very low. Also, despite quinine in tonic water being listed as having caused a serious reaction in one patient, Prof Maxwell said this was likely to be extremely rare.

Prof Maxwell said researchers should investigate if the grapefruit effect could be harnessed so lower doses of these drugs could be prescribed with the juice to allow the same clinical effect from less of the active medicine.

But this would be complicated and costly to study he said.

Leyla Hannbeck, Head of Pharmacy at the National Pharmacy Association said: “Grapefruit juice and fresh grapefruit can interfere with the action of a range of prescription and non-prescription drugs.

"In some cases this can result in potentially dangerous levels of the active ingredient in the blood.

"So if you have any concerns about how your diet could affect your medicines ask your pharmacist for advice. A face-to-face discussion with the pharmacist can be the key to safer and more effective medicines use.”

Ten drugs affected by grapefruits and the side effects it can cause:

Tyverb, for breast cancer – fast heart rate and bone marrow problems

Amiodarone, to prevent blood clots after surgery – fast heart rate

Clopidogrel, to thin the blood – becomes less effective

Dronedarone, for heart rhythm disorder atrial fibrillation – fast heart rate

Rivaroxaban, a blood thinning tablet to prevent stroke – stomach bleeding

Buspirone, for anxiety – dizziness and sedation

Fentanyl given orally for pain relief – slows breathing

Domperidone, for sickness – fast heart rate

Atorvastatin for high cholesterol – kidney poisoning

Simvastatin for high cholesterol – kidney poisoning

Offline Sym

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Re: NO GRAPEFRUIT-- more research and links
« Reply #1 on: January 04, 2013, 01:40:10 PM »
http://en.wikipedia.org/wiki/Bergamot_orange

the oil is used in earl grey tea

Bergamot orange

Bergamot is also a source of bergamottin which, along with the chemically related compound 6’,7’-dihydroxybergamottin, is believed to be responsible for the grapefruit juice effect in which the consumption of the juice affects the metabolism of a variety of pharmaceutical drugs.[19]

=======================

Grapefruit drug interactions - detailed w references

http://en.wikipedia.org/wiki/Grapefruit_juice_effect

=============

Bergamottin

http://en.wikipedia.org/wiki/Bergamottin

===========

Bergamot

http://www.bing.com/search?q=Bergamot&qs=n&form=QBLH&pq=bergamot&sc=8-8&sp=-1&sk=

Offline Egokiller

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Re: NO GRAPEFRUIT
« Reply #2 on: January 13, 2013, 10:32:03 AM »
Hi all Eboka Nation,

we all know that grapefruit should not be mixed with Iboga(aine), but check this report I found on one cite:

Grapefruits can trigger overdoses in dozens of medicines researchers warn

Millions of people taking medicines for high cholesterol, cancer and to prevent heart attacks are at risk of potentially life threatening side effects if they eat grapefruits, doctors have warned.

By Rebecca Smith | The Telegraph – 5 hours ago

A study has listed 43 major drugs which are affected by eating grapefruits or drinking the juice and experts have warned there needs to be more awareness of the risks.

The number of drugs that interact with grapefruit increased from 17 in 2000 to 43 in 2008, researchers in Canada found.

Eating one grapefruit a day or drinking 200ml of juice was enough to trigger significant side effects in some of the patients.

Elderly patients were at particular risk because they are more likely to eat grapefruit and be on the medicines that interact with it, while their bodies are less able to cope with the effects of an overdose, the researchers said.

Grapefruits and some other citrus fruits, contain specific chemicals that affects an enzyme in the gut which can lead to a greater proportion of the drug being absorbed into the body.

This can result in massive overdoses causing serious side effects ranging from hallucinations, low blood pressure, to kidney poisoning, muscle damage, high heart rate and breathing problems.

The findings were published in the Canadian Medical Association Journal.

Some people have died following the interaction and experts said doctors and pharmacists needed to be more aware of the problem.

The study, conducted by Dr David Bailey, of the Lawson Health Research Institute, in London, Ontario, listed several examples of interactions including one patient who suffered a potentially life threatening increase in heart rate while on the heart disease drug aimodarone and drinking between one and 1.5 litres of grapefruit juice a day.

Another one atorvastatin for high cholesterol suffered serious muscle damage after drinking freshly squeezed grapefruit juice daily for five days and one who developed a blood clot while on Ethinylestradiol, a form of hormone replacement therapy for menopause symptoms who had eaten a whole grapefruit at breakfast for three days.

Popular drugs affected in this way include simvastatin, taken for high cholesterol, clopidogrel to thin the blood, Tyverb for breast cancer, domperidone for sickness and powerful painkillers Fentanyl, Oxycodone and Ketamine.

One drug, dextromethorphan, is an anti-cough preparation used in over-the-counter products and other drugs that interact with grapefruit are some antibiotics, some anti-HIV drugs, quinine that is in tonic water and has been used against malaria, heart rhythm medicines, and anti-rejection drugs used following organ transplants.

For some drugs drinking 200ml of juice daily was enough to deliver three to six times the normal dose.

Dr Bailey said: "Many of the drugs that interact with grapefruit are highly prescribed and are essential for the treatment of important or common medical conditions.

"Unless health care professionals are aware of the possibility that the adverse event they are seeing might have an origin in the recent addition of grapefruit to the patient's diet, it is very unlikely that they will investigate it.

"In addition, the patient may not volunteer this information. Thus, we contend that there remains a lack of knowledge about this interaction in the general healthcare community."

The grapefruit effect can work in both ways, to reduce the amount of drug absorbed by the body, or to increase it, as was studied in this research.

Prof Simon Maxwell, Clinical Lead of Prescribing at the British Pharmacological Society and Professor of Clinical Pharmacology at the University of Edinburgh, said: "There are a lot of drugs on the list, including some very important high volume ones. But they represent a minuscule fraction of the compounds out there.

"Serious interactions are not a massive problem in Britain but we are probably not talking to our patients about it enough and awareness amongst doctors is definitely not high enough."

He said some of the interactions were theoretical such as dextromethorphan used in some cough mixtures as the amount of the active drug used in those medicines was very low. Also, despite quinine in tonic water being listed as having caused a serious reaction in one patient, Prof Maxwell said this was likely to be extremely rare.

Prof Maxwell said researchers should investigate if the grapefruit effect could be harnessed so lower doses of these drugs could be prescribed with the juice to allow the same clinical effect from less of the active medicine.

But this would be complicated and costly to study he said.

Leyla Hannbeck, Head of Pharmacy at the National Pharmacy Association said: “Grapefruit juice and fresh grapefruit can interfere with the action of a range of prescription and non-prescription drugs.

"In some cases this can result in potentially dangerous levels of the active ingredient in the blood.

"So if you have any concerns about how your diet could affect your medicines ask your pharmacist for advice. A face-to-face discussion with the pharmacist can be the key to safer and more effective medicines use.”

Ten drugs affected by grapefruits and the side effects it can cause:

Tyverb, for breast cancer – fast heart rate and bone marrow problems

Amiodarone, to prevent blood clots after surgery – fast heart rate

Clopidogrel, to thin the blood – becomes less effective

Dronedarone, for heart rhythm disorder atrial fibrillation – fast heart rate

Rivaroxaban, a blood thinning tablet to prevent stroke – stomach bleeding

Buspirone, for anxiety – dizziness and sedation

Fentanyl given orally for pain relief – slows breathing

Domperidone, for sickness – fast heart rate

Atorvastatin for high cholesterol – kidney poisoning

Simvastatin for high cholesterol – kidney poisoning


I totally dont believe you forgot to add the most deadly  when combined together can cause a serious overdose,, Xanax & Methadone, that was honestly my fave deadly mix was 100 mgs methadone from clinic, snort a bar sometimes 2 and have grape fruit juice.  Ive fallen off many a toilets and woke up with dried up blood from my nose :-[   Im writing this cause your post reminded me of how I learned about how grape fruit juice poteniates the hell out of some medications,   We used to act like we would puke up at clinic cause hey would redose something like 50% of your dose so one day the nurse at window tells everybody that to drink grape fruit juice, said it would make it last longer, hell she may have said to drink it in evening cause she new that because now that I think about it I didnt have take homes and i wanted to split my dose cause I could never make it to morning without cold sweats.  Thats where I learned of that.  So it could infact strengthen a flood If  you watered down your juice and drank that with the flood IF ya puked only if ya puke. Notice that was a big if but Im proned to pukeing :( and my last flood fail was this past Dec 29, I wanted to start year off rite and instead of having my lasagna dish I puked it up but held it in my mouth thinking I got this, Im just gonna reswallow this so I try that a couple times and it just gets to unbearably that I release it in toilet :( :( Now im thinking cause i recently puked it up, what if I had had grape fruit juice??? I wonder what is a safe amount cause im sure this could be a good thing for us that have bad stomaches, and need it cranked up a bit I mean at this moment I have a post up seeking for info on anal administration cause there will be NO PUKEING 8)  You folks seem to like to share info ;) Do you have any updated info you could give me on the post I just bumped, The Iboga anal one? 
MY OVERDOSE WITH IBOGA & WHY YOU NEED A SITTER!!!!
http://eboka.info/index.php?topic=1804.0