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Topics - mycotheologist

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I watched Chris Jenks interview and he said for every 2kg of RB, he used 4.5mL of water and 1.5L of vinegar or something like that and they're the proportions I went by. I started reading his extraction manual though and he says something different. He says for every kg of RB, to use 1.5L of vinegar. Also, I can't find any mention of how much water to use in the manual. I assume you have to add water because when I added the 7mL of vinegar and 25mL of water (I can't remember the exact volumes but it was something like that), I could barely even wet all the powder so I ended up adding a bit more water. If I only added 7mL of vinegar, it woulda just got absorbed by the powder.

I read that ibogaine HCl has a shelf life of about 3 years. The freebase alkaloid will be lower than that. I did a whole class on pharmaceutical formulation in college so I know a thing or do about this so I'll write a basic guide on increasing shelf life. Degradation doesn't just magically happen for no reason, its things in the environment that causes it to happen. Firstly, acidity accelerates degradation and one major way acidity is introduced by the environment is carbon dioxide. When CO2 dissolves in water, it forms carbonic acid. The obvious way to protect against this is to keep the sample dry. Its very easy to keep things dry, just make a little tissue pouch of calcium chloride and keep it in the bag with extract. Otherwise just get one of those silica bags that they put in shoes and stuff.

Another major cause of degradation is free radical attack. An obvious way to prevent this is to add an antioxidant. In some pharmaceutcal preparations in which the active compound is susceptible to free radical attack, they add vitamin C. Being a vitamin thats required by the body in large quantities, its an excellent choice for an antioxidant.

Oxidation is another major cause. My knowledge is a little rusty, I can't remember how to prevent this. I think it might actually occur via a free radical mechanism, so if thats the case then vitamin c would work. Vitamin C is ascorbic acid. If dilute vinegar is strong enough to react with the iboga alkaloids, I bet ascorbic acid is too so you could convert your iboga alkaloids into ascorbate salts. Never heard of ibogaine ascorbate before. I'll do some research later and update the thread.

Although this may sound like jibberish to someone with no chemistry background, I'll try explain a bit of the theory behind why compounds degrade, using ibogaine as an example.

Heres ibogaine:

In organic chemistry, to get an idea of how a compound will react, you look for any reactive functional groups on it. Aromatic rings are relatively stable (so the hexagon won't react easily) and alkyl chains are pretty stable (so that darker, square looking thing sticking out of the right of the molecule won't react easy). Heteroatoms (atoms that aren't carbon) are usually more reactive. On the left hand side of the molecule, theres a methoxy group, and they are susceptible to various types of reactions. For example, acid catalysed demethylations can occur. If that happened, the methoxy group (-O-) would turn into a hydroxy group (-OH), if it the acid was HCl, then a chlorine atom migth even be attached to it. In this case, we're safe because vinegar is nowhere near strong enough acid to do that.  They can also undergo oxidations but I can't really remember how that works.

Alkyl groups are usually stable but that depends on what they are attached to. Look at the 7 membered ring on the right, theres one carbon attached to the pyrrole ring and the carbon next to it is attached to a nitrogen atom. The pyrrole ring is electron withdrawing so the carbon next to it is not that stable. Similarly, the carbon attached to the nitrogen atom is not that stable. I can't remember the specifics on how these carbons can be attacked, I need to do a bit of revision.

Finally, the amino groups themselves are targets for degradation. I don't know anything about how they contribute to degradation though so I'll leave it at that. I'll update the thread when I know more.

Eboka Preparations & Extractions / Degradation of iboga alkaloids
« on: November 28, 2012, 05:47:50 PM »
I did an extraction on 30g RB myself and ended up with only 250mg which is a terrible yield, and I didn't even bother to filter the product because it was clogging up the filter and I didn't want to lose my product on the coffee filters. For some kind of filtrations, you really need to do a vacuum filtration with a Hirsch funnel. I have the apparatus for that but no vacuum source. I'm going to convert a bicycle pump into a vacuum pump soon enough, it looks pretty easy to do that.

After researching it, it seems, like gratefuldad said, iboga alkaloids are susceptible to degradation. After I added the vinegar and water and extracted the plant mass, I boiled some of the liquid off which is one of the worst things I could of possibly done because both heat and acidity accelerate degradation. Also, instead of filtering the precipitated freebase alkaloids, I let it settle to the bottom of the beaker, siphoned off the liquid at the top then evaporated the rest. Another big mistake because freebase alkaloids are even more fragile than the salts. I'm worried now that my product will be contaminated with degradation products. Some of those degradation products might be active so God knows what effects they might have.

Has anyone here done an extraction as disasterious as my one and tested the product? If so, did it have any adverse side effects?

Eboka Preparations & Extractions / Soxhlet extraction with acetone
« on: November 26, 2012, 07:14:07 PM »
Anyone here tried a Soxhlet extractor for iboga extractions? The solvent I'd use is acetone because the freebase alkaloids are soluble in it, it has a low boiling and its aprotic (which means its less likely to react with the alkaloids). I don't have a soxhlet extractor so I can't test this out yet.

Eboka Talk / Is it safe to work your way up to a flood alone?
« on: November 04, 2012, 10:59:22 AM »
I've read enough posts on this forum to shiver at the thought of doing my first flood alone. I've been microdosing with RB every day and gradually increasing my doses and I'm wondering if one can gain experience and get a feel for iboga and therefore, make themselves better able to handle a flood like this. So far its just making me euphoric, energetic and giving me mild visuals. Is there a thin threshold between microdosing and psychedelic doses? Meaning could taking just an extra gram make the experience unmanagable?

General Discussion / Tracers?
« on: November 04, 2012, 10:53:34 AM »
For the past few days, when I move my arm or any other object past my field of vision, its followed by a slow motion ghost arm. Its very trippy. It kept me entertained for about 2 hours last night. Is this what people refer to as "tracers"?

I've started microdosing and one of the main effects I'm getting is euphoria. A sense of well being and lots of energy. Is this a good sign that iboga agrees with me? In other words, does it mean I will be able to handle higher doses? I'm pretty nervous about the prospect of a flood, right now I'm just gradually accumulating the iboga in my body and seeing how it goes.

General Discussion / Iboga and dreams
« on: November 02, 2012, 01:32:22 PM »
I started microdosing iboga rootbark (3 teaspoons per day, I don't have a scale on me so I'm not sure how much that weighs) and some definite effects I've noticed is that my dreams last night were insanely vivid. I become lucid regularly in dreams and I remember last night thinking that I must have taken a new substance that is effecting my dreams because everything was hyper vivid, it was only when I woke up that I remember I had done iboga rootbark the day before. I've also noticed that I can now see visions when I close my eyes at any time, usually that only happens right before I fall asleep. Fascinating stuff.

I read about a woman in the Netherlands who had been treating people with iboga for years and recently, one of her patients decided leave during the therapy and she couldn't stop him. At some point or another he walked onto a motorway and got killed by a car. The woman was arrested. I think thats akin to arresting the doctor because one of their depressed patients commit suicide which is ridiculous IMO but thats how the law works. I will be doing iboga therapy with someone in the Netherlands, someone who I have a great deal of respect for. I know there is a 1% chance of dying during iboga which is very low but I'm an unusual case in the sense that I changed my brain chemistry from using all kinds of substances over a 6 month period including GHB, phenibut, benzos, amphetamines, opioids etc. so its pretty much uncharted territory in my case. If I were to write and sign a document that states that the therapist is in no way responsible for my death and that I was fully aware of the risks and took those risks out of my own will, would that protect him legally? I know its extremely unlikely that I will die but if it were to happen, I wouldn't want it to result in this person losing his ability to treat people and possibly his freedom too.

General Discussion / Does iboga interact with antidepressants?
« on: September 23, 2012, 01:43:32 PM »
I quit benzos but I've been taking trazodone to sleep every night and I don't know if I can easily stop taking the trazodone. I have a 5 day iboga treatment scheduled for next month and I'm wondering what to do about the sleep issue. I hear iboga gives one insomnia so considering I already have a problem with insomnia, I may get it real bad. I'm wondering if I can take trazodone to sleep each night during this treatment. I'll be doing iboga every evening, with increasing doses each evening.

Micro-Dosing / Iboga and benzo tolerance
« on: September 04, 2012, 09:25:09 AM »
I read a report on bluelight I think it was in which someone claimed to have microdosed with iboga for a summer while using a wide variety of psychoactive substances including opioids and claimed that he developed no tolerance to these substances and thus, no withdrawal. I'm starting my final year (the most important one) of college soon and I'm going to start microdosing with iboga in a few days to see if it solves my drowsiness problem and trouble concentrating but I'm anticipating that I might get anxiety because I quit xanax a few weeks ago and have some very mild withdrawal symptoms which seem to be amplified by certain substances (opioids and gabapentin greatly amplify the w/d symptoms). I stocked up on xanax so I have something to fall back on if things go wrong. I'm wondering if iboga prevents the buildup of tolerance to benzos, like it does with opioids. I've heard that iboga greatly amplifies the effects of opioids. Does it do the same with benzos? I read many threads on this forum so I know that benzos are safe to use with iboga, even during a flood (a couple of people who had severe panic attacks during a flood were given IV ativan and it solved the problem).

General Discussion / Kambo - Is there a risk of walking around?
« on: August 08, 2012, 01:28:29 PM »
I know a good secluded spot within walking distance from my house, its a grass patch but its right beside a rocky beach. If I were to stumble onto the beach I'd probably break a few bones since the rocks are hard enough to walk on sober. If I made it to the sea I'd drown. Are you completely immobilised on kambo or do you walk around?

Eboka Talk / How important is setting for kambo?
« on: August 04, 2012, 12:16:42 AM »
I found somewhere to participate in an ibogaine therapy session but I want to prepare myself with kambo well in advance. I also think that kambo alone will cure many of my ailments so I'm looking forward to starting. My plan is to use kambo once a month, during the months leading up to my ibogaine experience. I'm thinking of doing this at home by myself. Since one is able to function again within 30 minutes, I don't see a problem with this and I can easily setup a safe environment for a short experience like that. I know that doing it in the Amazon jungle under the guidance of a South American shaman would be the optimum setting for it and I would gain far greater physical and spiritual therapeutic effects that way but will I be able ot gain a reasonable amount of the therapeutic benefits by using it at home like this?

General Discussion / Iboga for mild benzo PAWS
« on: July 24, 2012, 08:27:28 AM »
Can low doses of iboga help the brain recover in order to cure mild benzo PAWS? My only real PAW is this nervousness/depression that won't seem to go away, I've been sleeping 8 hours a night and everything else is normal but this PAW is interfering with my life a lot since I have a problem with drowsiness and this PAW prevents me from taking any stimulants or finding other ways to counteract the drowsiness. I'm considering ordering some rootbark and taking 1g/day to see what that does for me. If I'm brave enough and can find a sitter, I may take 10g at one point but I'd really rather not do a psychedelic dose any time soon. Not with bark anyway, I'd prefer to do it with HCl.

Staying Clean / Microdosing with iboga root bark to cure PAWS
« on: July 24, 2012, 08:08:41 AM »
Hi, I experimented with GABA agonists for 6 months and I thought I was avoiding physical addiction by switching between phenibut (a GABA_b agonist) and benzos (GABA_a agonist) and while I had no acute withdrawal after quitting, I have this nervous/depressed feeling which has lasted a month so far. Can microdosing with iboga root bark cure this? I don't want to experience full on psychedelic effects because I won't have a sitter etc.

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