I was in full on vision mode before I ever threw up my first time, and the other times, I held it in for a very long time before puking. It definitely wasn't all absorbed even four hours after eating crude vinegar extract, one of the times, as it was all I could taste when I threw up, and it didn't really hit me full strength until I puked. I think a lot of that was due to it absorbing in my mouth from my throw up. I am unsure of nausea medications, but I wouldn't bother, although I have read of one that some have used to help.. I forget the name of it, unfortunately.. Staying still and focusing on something else should make it easy to hold down until it all kicks in. I found, also, that poking a pin hole in the end of the capsule of extract before swallowing it helped it absorb faster..